Endocrine Abstracts

BackgroundPrader Willi syndrome (PWS) is a genetic disorder with a broad clinical expression. Severe hypotonia with feeding difficulties during early infancy and delayed motor development are very characteristic. At older ages, common motor features in the PWS phenotype include decreased muscle strength, deficiencies in motor coordination and sequencing, gait disturbances and dyspraxic manifestations, with no clear pathophysiological mechanism yet identi...

BackgroundCentral kisspeptin action is well known in reproductive regulation; however, its peripheral action is not well understood. Most studies reveal that kisspeptin signaling influences energy and metabolic status.ObjectiveTo compare serum kisspeptin levels 1) between adult patients with PWS, obese subjects matched for age, sex and BMI and healthy subjects; 2) in adult patients with PWS before and after t...